本劇是繼2001年開拍的電視劇《神醫(yī)喜來樂》（2003年播出）成就經(jīng)典的十年之后，原班主創(chuàng)再續(xù)前緣的姊妹篇，由周振天擔綱編劇、李保田領銜主演、柏杉升任導演。全劇延續(xù)前部故事和風格，情節(jié)更加跌宕起伏、角色形象更加豐滿鮮活，并有全新人物登場。作品講述了庚子年間，因得罪權貴被發(fā)配東北的神醫(yī)喜來樂一家又被卷入時代的漩渦：喜來樂的死對頭向洋人舉薦其當軍醫(yī)；國難當頭，宮廷內(nèi)斗卻依舊未曾停息……
張路(徐路飾)全力搶救一個叫小敏的受傷女患者，張路盡了最大努力，但小敏還是因為大出血而離開了這個世界。小敏的母親杜麗(宋春麗飾)悲痛欲絕，對張路興師問罪，認為是張路的失職導致女兒的離去。杜麗的身后站著一個更具威脅的人物，小敏的繼父全武(姜武飾)，身為偉業(yè)藥業(yè)集團董事長的他，在這個城市是手眼通天的人物。但他意外發(fā)現(xiàn)張路竟然是5年前被自己撞傷的同事張文學的女兒。杜麗以報復殺人罪欲將張路送上法庭，卻被老謀深算的全武制止，他這樣做是為了掩蓋一個5年前的秘密。
As Leo's replacement Thomas Chamberlain arrives Nikki investigates the murders of Rachel Freedman, shot in the head, and her little autistic son Nathan, who was poisoned. Nikki rejects policewoman Anne Burchett's theory that Rachel killed them both but is perturbed when an impostor, claiming to be Rachel's sister, visits the morgue. At the same time the disfigured corpse of Eva Liron is discovered, killed with the same poison as Nathan. She had been the nanny to French hot shot footballer Isaac Dreyfus and was planning to blackmail him over a sex tape of them both. Jewish Isaac is a controversial figure due to his anti-Muslim sentiments but he denies ant part in the murders. Then another victim, Isaac's agent Mousa, is discovered dead.
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