As Leo's replacement Thomas Chamberlain arrives Nikki investigates the murders of Rachel Freedman, shot in the head, and her little autistic son Nathan, who was poisoned. Nikki rejects policewoman Anne Burchett's theory that Rachel killed them both but is perturbed when an impostor, claiming to be Rachel's sister, visits the morgue. At the same time the disfigured corpse of Eva Liron is discovered, killed with the same poison as Nathan. She had been the nanny to French hot shot footballer Isaac Dreyfus and was planning to blackmail him over a sex tape of them both. Jewish Isaac is a controversial figure due to his anti-Muslim sentiments but he denies ant part in the murders. Then another victim, Isaac's agent Mousa, is discovered dead.

　　Following a court appearance for drunk driving, Leo is required to perform unpaid work as a punishment, assisting AJ, a community worker on a run-down,largely black-occupied housing estate in South London. AJ is hoping to divert boys away from crime by encouraging them to do sports, and, though initially dismissive of Leo as a white intruder, comes to respect him after he has saved the life of Errol, a former gang member now anxious to keep his little brother Levi out of trouble. Errol has been stabbed in the leg by members of a gang from a rival estate and Leo stops him from bleeding to death. Earlier in the week a young girl called Shana Block was stabbed to death at a funfair and her murder recorded on a mobile phone. As Shana lived on the estate police sergeant Wallace involves Leo as a go-between with the suspicious residents. Also on the scene are Harry and Nikki, the latter dating Ryan, a young Scottish paramedic she met when called to the scene of Shana's death.

　　The pathologists investigate when a military helicopter crashes into a refugee detention center. Harry and Nikki actually witnessed the crash and were first on the scene but the case is complex since the center was Ministry of Defense property leased to the Home Office. The team is shocked at the conditions they find in the center and Harry, who has a close friend in the RAF, is shaken when a government Minister attributes the accident to pilot error.

　　When a boat carrying illegal passengers is found crashed in the Thames, the team investigate.

　　The team is shocked when Leo Dalton's wife and daughter are killed when a fancy sports car careens out of control and smashes into a café. The police are puzzled by the cause of the crash but believe the driver may have been involved in a identity theft ring when they find several several passports and ID cards in the vehicle. Meanwhile, Nikki must perform urgent autopsies on two bodies found floating in the river.

　　A Time to Heal -The team is called out to Northern Ireland to investigate the bodies of two men killed by paramilitaries twenty years ago. For Sam, it is a case that is soon to turn personal…
　　Death by Water - Tensions are running high in the ‘leaderless’ team as Leo and Harry clash over an investigation into an outbreak of breathing difficulties among children on the South Coast.
　　Nowhere Fast - When members of a race horse owning syndicate are killed in a helicopter crash, Leo and Harry investigate – and an unexpected new face at the mortuary lends a helping hand.
　　Body 21 - Approached by a group of survivors from a recent train crash, the team investigate the wreckage and a new mystery – the identity of the unidentified body 21.

　　本劇改編自豆瓣閱讀連載小說(shuō)《一生懸命》，作者、編劇陸春吾。
　　倪向東（尹昉 飾）收到好友曹小軍（白宇帆 飾）的請(qǐng)求，將一只木箱運(yùn)送到荒山上的廢棄小屋，卻意外發(fā)現(xiàn)箱里裝的竟是曹小軍的尸體。曹小軍的妻子吳細(xì)妹（李庚希 飾）報(bào)警尋找失蹤的丈夫，并暗指一切都和倪向東有關(guān)?？勺鳛樽C人，吳細(xì)妹的供詞前后矛盾，且夫妻二人的孩子并非曹小軍親生。在警方的連環(huán)追問(wèn)下，吳細(xì)妹迫不得已講述了三人的往事。
　　三人曾是好友，吳細(xì)妹與倪向東是一對(duì)戀人，倪向東不愿為孩子負(fù)責(zé)，曹小軍挺身而出帶她遠(yuǎn)走高飛，一起撫養(yǎng)孩子。在追查過(guò)程中，警方進(jìn)一步發(fā)現(xiàn)吳細(xì)妹的孩子和倪向東也沒(méi)有血緣關(guān)系，大家對(duì)倪向東的評(píng)價(jià)還存在完全不同的兩種聲音：老家的人說(shuō)倪向東無(wú)惡不作；工友卻說(shuō)他與人為善，還資助了一位姓徐的老人。
　　老警員孟朝（張哲華 飾）帶著新人童浩（徐奧俊 飾），從北方海岸到南方密林，抽絲剝繭，揭開(kāi)了吳細(xì)妹、曹小軍、倪向東糾纏了十余年的連環(huán)殺局，讓作惡之人得到了法律的制裁。

　　這是一部展示我國(guó)緝毒警察智勇雙全，與販毒犯罪分子展開(kāi)殊死斗爭(zhēng)的故事。
　　某市一連串發(fā)生命案，經(jīng)調(diào)查這都與涉毒有關(guān)，為此，公安局張局長(zhǎng)指示刑警隊(duì)隊(duì)長(zhǎng)雷霆成立專(zhuān)案小組偵破這些系列販毒案，派出所治安警沙城也加入刑警隊(duì)專(zhuān)案小組。在辦案過(guò)程中，隊(duì)長(zhǎng)雷霆等干警發(fā)現(xiàn)新型毒品已經(jīng)開(kāi)始滲入某市。為了打擊制毒犯罪團(tuán)伙，追查制毒配方的來(lái)源，公安局領(lǐng)導(dǎo)安排年輕的女刑警張葉和沙城一起到大學(xué)化學(xué)樓展開(kāi)調(diào)查，張葉和沙城在調(diào)查中發(fā)現(xiàn)科技精英宮教授竟然是罪惡的幫兇。為了引出毒梟昆哥，雷霆派張葉只身進(jìn)入敵穴展開(kāi)智與勇的較量，終于在兩代警員的共同努力下，破獲了一個(gè)利用娛樂(lè)城販毒的犯罪團(tuán)伙。

　　經(jīng)過(guò)千挑萬(wàn)選，沃威（萬(wàn)思維 飾）、姜竇（蒲巴甲 飾）等一批有志青年被選到陸航大隊(duì)，在教官鄭北（王強(qiáng) 飾）帶領(lǐng)下，組成了一個(gè)全能型飛行特訓(xùn)班。學(xué)員們出身不同、秉性各異，組建之初就略見(jiàn)分曉。在嚴(yán)格的訓(xùn)練中，以鄭北為首的教官隊(duì)伍針對(duì)學(xué)員特質(zhì)，制定了非常規(guī)教學(xué)手段，為培養(yǎng)新時(shí)期后備人才做了探索性試驗(yàn)。急流勇進(jìn)、大浪淘沙，學(xué)員們?cè)谟?xùn)練中顛覆自我，展現(xiàn)了一幅幅狹路相逢、絕處逢生的青春畫(huà)面。有的人自感得意時(shí)遭淘汰，也有的遇坎坷自我迷失，更有甚者陷入情感糾葛。在不斷斗智斗勇中，學(xué)員與教官、上級(jí)與下級(jí)、男學(xué)員與女教官，上演著環(huán)環(huán)相扣的明暗斗法。最終使大家理解了什么是“戰(zhàn)友”......

　　本劇講述了四個(gè)美麗睿智的女孩何茹、林依蘭、小辣椒和安子背井離鄉(xiāng)到南濱打工的故事。她們雖然同時(shí)漂泊在海濱，但對(duì)生活的態(tài)度及命運(yùn)卻截然不同，她們經(jīng)歷著欲罷不能的戀情；經(jīng)歷著一同歡笑一同流淚而又矛盾重重的友情；經(jīng)歷著對(duì)未知?dú)w宿的迷茫和生離死別的變遷……