It’s never too late to make a change in your life. Attilio, Giorgetto, and the “Professore,” three retired men from Rome, are tired of their daily struggle; they dream of escaping to someplace exotic. They begin to save up the necessary money but it’s hard to break their habits. Di Gregorio continues his story of harmlessly eccentric men. With him, Giorgio Colangeli and Ennio Fantastichini in his last, very dynamic performance.

　　《大夢西游4伏妖記》是一部由馬中軒執(zhí)導(dǎo)、謝苗、南笙、樊蕊、李波兒、白梓軒、杜玉明、程茉、王乙帆、陳茉、曹筠妮、易正福、陳久龍、馬君戈等共同出演的影片，樊蕊繼在《大夢西游3女兒國奇遇記》中飾演女兒國國王后，再次加盟大夢西游系列，并在《大夢西游4伏妖記》中飾演霸氣外露的蜘蛛精大姐，與高顏值全能藝人白梓軒所飾演的唐僧塑造一對相愛相殺的搞笑的故事。

清末民初時期，讀書文人皆不重氣節(jié)，急功好利，凡事盡為一己之私;劇中敘述一段人鬼奇戀，點出讀書之所以為用，非只是加官晉碌，進而達經(jīng)世濟民之實;劇中之劇情，弦外之意頗深，耐人尋味……